健康婴儿LH、FSH、雌二醇与睾酮的血清浓度

Serum concentrations of LH, FSH, estradiol and testosterone in healthy infants

目的研究正常婴儿血LH、FSH、雌二醇(E2)与睾酮(T)的血清浓度变化.方法用免疫化学发光分析法对358名正常婴儿(男婴183,女婴175)的LH、FSH、E2和T水平进行测定,同时对3个月内婴儿的其他可能相关指标(出生体重、孕期、胎次、母亲年龄及分娩方式)进行了研究.结果(1)婴儿期4种激素水平变化:男婴LH、FSH在2～3月龄时达高峰(LH 3.5 IU/L,FSH 3.4 IU/L),6月龄后趋平坦(LH 1.5 IU/L,FSH＜1.5 IU/L),T在2～4月龄时达高峰(9.15 mmol/L)后快速下降,6月龄后稳定在一个较低的水平(＜1.34 nmol/L);女婴FSH在2～3月龄达高峰(7.1 IU/L),LH与T在整个婴儿期的水平几乎是条直线(LH＜4.7 IU/L,T＜2.49 nmol/L).男女婴的E2水平在生后快速下降,3月龄后达最低值.(2)性别差异:LH和T在6月龄前男婴明显高于女婴,6月龄后无性别差异.FSH水平各月龄组女婴均高于男婴,E2除2月龄前女婴高于男婴外,3～12月龄时无性别差异.(3)3月龄内婴儿促性腺激素、性激素水平与出生体重、孕期、胎次、母亲年龄及分娩方式未显示相关关系.结论婴儿在2～4月龄时的血促性腺激素与性激素水平有个暂时的高峰期,并有明显性别差异,可能与两性性腺发育的不同调控机制有关.

Objective To investigate the changes of serum LH, FSH, estradiol and testosterone in healthy infants. Methods Serum samples were obtained from 358 infants （ 183 boys, 175 girls） aged from 1 month to 12 months. LH,FSH,estradiol and testosterone concentrations were determined by chemiluminescence immunoassay. Factors （birth weight, gestational age, birth order, maternal age and labor type ） associated with these four hormones were recorded within 3 months after delivery. Results （ 1 ） In boy infants, peaks of serum LH and FSH concentrations were observed at 2 - 3 months of age （ LH 3.5 IU/L; FSH 3.4 IU/L） , then decreased to low concentrations （ LH 〈 1.56 IU/L; FSH 〈 1.5 IU/L） after 6 months of age, and serum testosterone concentrations reached peak （9.15nmol/L） at 2 -4 months of age, then decreased rapidly, and remained low （ 〈 1.34 nmol/L） after 6 months of age in boy infants. In girl infants, serum FSH concentrations reached peak （7.1 IU/L） at 2 -3 months of age. There were little changes in serum LH and testosterone concentrations in female infants （ LH 〈 4.7 IU/L; testosterone, 〈 2. 49 nmol/L）. Serum estradiol concentrations decreased significantly after birth to the lowest concentrations after 3 months of age in both sexes. （ 2 ） During the six months following delivery, serum testosterone and LH concentrations were significantly higher in boy infants than that in girl infants, whereas concentrations of FSH were higher in girl infants than that in boy infants. Serum estradiol concentrations did not differ between genders in all age groups except in the -2 months old groups （girl infants 〉 boy infants）. （3） No correlations were found between serum concentrations of these four hormones and birth weight, gestational age, birth order, maternal age, labor type before 3 months （ P 〉 0.05 ）. Conclusion Peaks of serum gonadotropin and sex hormone concentrations are reached at 2 -4 months of age and sexual dimorphism is shown, suggesting that in boy and girl infants, different mechanisms may be involved in regulating the development of gonads.