摘要
2型糖尿病大鼠成模后2周进行离体心脏灌注,显示心肌葡萄糖摄取能力降低,葡萄糖氧化减少、脂肪酸氧化增加,高能磷酸盐合成减少,这可能是糖尿病易发生心肌病和在缺血条件下心肌损伤更趋严重的代谢基础。
Isolated hearts of type 2 diabetic rats were perfused with K-H buffer containing glucose and ^3H-labeled palmitate by a Langendorff perfusion apparatus. The results revealed that glucose uptake by hearts of diabetic rats was significantly depressed, glucose oxidation was decreased and palmitate oxidation was increased. The myocardial ATP content declined gradiently. Change in energy substrate utilization seems to be a significant factor contributing to cardiomyopathy and rendered diabetes more vulnerable to ischemic injury.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2005年第6期567-568,共2页
Chinese Journal of Endocrinology and Metabolism
