猪脊髓前角匀浆免疫后豚鼠脊髓前角运动神经元的超微病理特征

Ultrastructural study of spinal cord ventral horn motor neurons in Guinea pig immunized by swine spinal cord ventral horn homogenate

应用透射电子显微镜观察猪脊髓前角匀浆免疫后豚鼠脊髓前角运动神经元的超微结构改变,并进一步探讨其发病机制。结果显示:免疫后豚鼠脊髓前角运动神经元可见内质网扩张、线粒体肿胀;胞浆基质及细胞器致密化;有髓神经纤维内神经丝局部积聚、大量线粒体及溶酶体聚集;前根及坐骨神经大的有髓神经纤维轴索萎缩,髓鞘结构保存相对较好。以上结果提示自身免疫机制能诱导脊髓前角运动神经元的损伤,轴浆转运异常可能参与其致病过程。

The ultrastructural characteristics of motor neurons in spinal cord anterior horn in guinea pig immunized with swine spinal cord ventral horn homogenate were observed by using transmission electron microscopy. The results showed dilation of endoplasmic reticulum and swelling of mitochondria in motor neurons of spinal cord ventral horn in immunized guinea pigs. Some neurons displayed compaction of cytoplasmic matrix and organdies. Accumulations of neurofilaments, numerous of mitochondria and lysosomes were observed in some axons of myelinated nerve fibers. Axons of large myelinated nerve fibers in anterior root and sciatic nerve were atrophied with their myelin sheathes relatively conserved. It is suggested that autoimmune mechanism can induce injury of motor neurons of spinal cord ventral horn. Abnormal axoplasmic transportation might have an role in the pathogenesis.