利多卡因用药方法和剂量的若干问题

ADMINISTRATION AND DOSAGE OF LIDOCAINE IN TREATMENT AND PREVENTION OF VENTRICULAR ARRHYTHMIA INDUCED BY ACUTE MYOCARDIAL INFARCTION

对利多卡因防治急性心肌梗塞（ＡＭＩ）室性心律失常的用药方法和剂量结合４６例ＡＭＩ进行了临床观察和探讨。认为常规静脉冲击５０ｍｇ继以１ｍｇ／ｍｉｎ静脉滴人的剂量偏小，用利多卡因前、后室性心律失常的发生率分别为３０／４６（６５．２％）和３９／４６（８４．７％），利多卡因未能防治室性心律失常的发生。作者认为，冲击量以１ｍｇ／ｋｇ继以２～３ｍｇ／ｍｉｎ静脉滴入的剂量似较妥。本文对利多卡因的给药方法、剂量以及注意事项进行了探讨。

The prophylatic and therapeutic effects of lidocaine(LDC)onventricular arrhythmia(VA)induced by acute myocardial infarction(AMI)wereobserved,and administration,dosage and caution of LDC were further studied in 46cases of AMI.It was found that after treatment of AMI with routine dosage,i.e.,LDCwas given initially as an intravenous bolus iniection of 50mg over a one-minute period,followed by a constant infusion of lmg per minute,the occurrence rate of VA was higherthan that before acministration of the drug,which were 84.7%and65.24%respectively,This findings suggest that the routine dosage is on the low side for maintainingtherapeutic blood levels,therefore it can not prevent AMI-induced VA.According to thestudy and clinical experience,the authors consider it to be appropriate dosage fortreatment and prevention of AMI-induced VA that the LDC should be given initiaIIy as anintravenous bolus injection of 1mg/kg and subsequently as continous drip of 2～3mg per minute.