阿尔茨海默病精神行为异常的综合干预研究

The Study of Synthetic Intervention in Behavioral and Psychological Symptoms of Alzheimer's Disease

目的了解综合干预措施对伴有精神行为异常的阿尔茨海默病(AD)的效果。方法56例AD患者随机分为研究组(综合干预)与对照组(单纯药物干预)各28例,在干预前、干预后2月、干预后12月用阿尔茨海默病病理行为评分表(BEHAVE-AD)、简易智能状态检查(MMSE)、日常生活能力量表(ADL)进行效果评定、比较。结果两组患者干预后BEHAVE-AD总分及各因子分评分均较干预前明显降低,差异有显著性(P<0.05;P<0.01);在干预后12月研究组的BEHAVE-AD总分及妄想、攻击行为、行为紊乱、情感障碍、焦虑恐惧因子分均低于对照组,差异有显著性(P<0.05;P<0.01);研究组MMSE、ADL评分在干预后12月较干预前有显著改善(P<0.01),且显著优于对照组(P<0.05)。结论综合干预措施对改善AD患者精神行为症状有效,可推广应用。

Objective To investigate the effect of synthetic intervention on behavioral and psychological symptoms of Alzheimer＇s disease （AD）. Methods Fifty-six patients with AD were randomly assigned into the investigation group and control group. They were tested by Behavioral Pathology in Alzheimer＇s Disease Rating Scale （BEHAVE-AD）,Mini Mental State Examination （MMSE） and Activity of Daily Living Scale （ADL） before and two months and twelve months after intervention. Results The total scores and all factors scores of BEHAVE-AD of two groups of patients after intervenation were significantly lower than those before intervenation （P〈0.05 ;P 〈0.01）. In twelve months after intervention, the total scores and the scorces of delusion, aggressive behavior, conduct disorder, affective disorder, anxiety and terror in the investigation group were significantly lower than those in the control group （P〈0.05;P〈0.01）. The scorces of MMSE and ADL in the investigation group in twelve months after intervention were significantly improved than the those before intervention （P〈0. 01）, and significantly prior to those in the control group. Conclusion The synthetic intervention has efficacious on behavioral and psychological symptoms of AD,and it could be generalized and used.