大剂量α-干扰素静脉注射治疗丙肝病毒相关性肾炎

Treatment of HCV associated glomerulonephritis with large dose of α-INF

本文首次在国内报道大剂量α-INF静脉疗法治疗2例HCV相关性肾小球肾炎．肾活检诊断1例为隐性肾病，另1例为膜增值性肾炎．运用RT－PCR方法检测肾组织中HCV－RNA，均有负链和（或）正链的阳性结果．本文结果及文献报道提示，大剂量α-INF静脉疗法治疗HCV相关性肾小球肾炎可抑制HCV病毒复制，减轻HCV病毒血症，从而缓解由HCV免疫复合物导致的肾脏病变，包括肾功能及尿蛋白等．该法疗效肯定，副作用少，但停药后易复发，且价格昂贵．

Alpha interferon (α-INF) is currently approved in the Western countries for the treatment of chronic hepatitis C virus infec-tion (HCV) associated glomerulonephritis,however, there is not any report in China.We treated two patients with HCV associat-ed glomerulonephritis with high dose of in-travenous a-lNF (3 000 000 U 3 times per every week for 16 weeks ), who were di-agonsed membranous nephropathy and mesangial capillary proliferative nephritis by renal biopsy, and negative and/or posi-tive HCV-RNA chains were detedcted in re-nal tissues with the use of RT-PCR method. Our results suggested that treat-ment with α-INF may be of benefit in sup-pressing the HCV viremia,reducing the pro-teinuria and stabilizing the renal function because HCV associated glomerulonephritis is likely to be mediated by the glomerular deposition of circulating HCV and anti-HCV antibodies,but clinical relapses are usual af-ter completing therapy,the cost is very ex-pensive,and long term and controlled stud-ies are needed.