染料木黄酮与肿瘤耐药
Genistein and drug-resistance of tumor
摘要
染料木黄酮(genistein)是一种新开发的天然药物,具有独特的肿瘤防治效果,可以增强很多耐药肿瘤细胞对常规化疗药物的敏感性,其人工合成类似物phenoxodiol在治疗耐药性卵巢癌的临床试验中疗效显著。
出处
《国外医学（肿瘤学分册）》
2005年第12期896-899,共4页
Foreign Medical Sciences (Cancer Section)
基金
国家自然科学基金资助项目(30472226)
参考文献19
-
1Li X,Marani M,Mannucci R,et al. Overexpression of BCL-X(L) underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells. Cancer Res,2001,61 (4) :1699-1706.
-
2Katdare M, Osborne M ,Telang NT. Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER-2/neu oncogene expressing human breast epithelial cells. Int J Oncol, 2002,21 ( 4 ) :809-815.
-
3Park SY, Seol DW. Regulation of Akt by EGF- R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis. Biochem Biophys Res Commun ,2002,295 (2) :515-518.
-
4Ikeguchi M, Kaibara N. Changes in survivin messenger RNA levelduring cispl atin treatment in gastric cancer. Int J Mol Med, 2001,8(6) :661-666.
-
5Ikeguchi M, Liu J, Kaibara N. Expression of survivin mRNA and protein in gastric cancer cell line ( MKN-45 ) during cisplatin treatment. Apoptosis,2002,7 ( 1 ) :23-29.
-
6Grossman D, Kim PJ, Schechner JS, et al. Inhibition of melanoma tumor growth in vivo by survivin targeting. Proc Natl Acad Sci USA,2001,98(2) :635-640.
-
7Suzuki K, Koike H, Matsui H, et al. Genistein, a soy isoflavone, induces glutathione peroxidase in the human prostate cancer cell lines LNCaP and PC-3. Int J Cancer,2002,99(6) :846-852.
-
8Mansour A, McCarthy B, Schwander SK, et al. Genistein induces G2 arrest in malignant B cells by decreasing IL-10 secretion. Cell Cycle,2004,3(12) :1597-1605.
-
9Sahi GI, Grewal S, Mehta RR, et al. Genistein induces apoptosis and topoisomerase Ⅱ-mediated DNA breakage in colon cancer cells. Eur J Cancer, 2000,36 ( 6 ) :796 - 802.
-
10Nguyen H, Zhang S, Morris ME. Effect of fiavonoids on MRP1-mediated transport in Pane-1 cells. J Pharm Sci,2003,92(2) :250-257.
-
1蔡震宇.生长抑素类似物与肝脏肿瘤[J].国外医学（生理病理科学与临床分册）,2002,22(4):357-359.
-
2田爽,辛晓燕,黄艳红.染料木黄酮对人卵巢癌细胞系抑制增殖和诱导凋亡发生的作用[J].国际肿瘤学杂志,2006,33(5):383-385. 被引量：5
-
3邹晓燕,张颐.染料木素对人卵巢癌裸鼠皮下移植瘤抑制作用及其机制的探讨[J].中华肿瘤防治杂志,2011,18(6):410-412. 被引量：2
-
4宋明智,张振,王寿宇,吕德成.植物雌激素类药物治疗骨肉瘤的基础研究进展[J].医学综述,2014,20(10):1778-1780. 被引量：2
-
5张娜,周琦,陆松梅,吴顺龙,刘双,何燕琼,李少林.汉黄芩素逆转卵巢癌SKOV3细胞对顺铂的耐药性[J].肿瘤,2016,36(2):166-172. 被引量：5
-
6周瑞芳,李幸运,刘鹏熙.植物雌激素相关中药对乳腺癌细胞增殖的影响[J].国际肿瘤学杂志,2006,33(11):838-841. 被引量：3
-
7王小艳,张洁.FDA批准Phenoxodiol为治疗复发性卵巢癌的快通道药物[J].中国处方药,2004(12):89-89.
-
8唐志坚,祝洪澜,王朝华,崔恒.卵巢上皮性癌内分泌治疗的新进展[J].中华妇产科杂志,2010,45(2):158-160. 被引量：1
-
9孙艳.靶向治疗对复发性耐药性卵巢癌的治疗价值分析[J].中国实用医药,2016,11(29):123-124. 被引量：3
-
10匡文娟,刘立涛,谭显曙,段迎,周黎明.毛蕊异黄酮对人乳腺癌MCF-7细胞作用的体外研究[J].肿瘤,2011,31(9):789-793. 被引量：1
