4-(4-甲基苯氧基)苄胺合成研究

Synthesis of the 4-(4-methylphenoxy)benzylamine

以对氯苯甲腈,对甲酚为起始原料,经醚化、还原两步合成4-(4-甲基苯氧基)苄胺。详细考察了缚酸剂、催化剂及氨水的影响,得到了产品合成优惠条件:n｛4-(4-甲基苯氧基)苯甲腈｝n∶(催化剂)n∶(氨水)=10∶.78～0.91.∶1,反应温度20～35℃,反应至原料消失。总收率(以对氯苯甲腈计)72%,产品含量96.5%。

Four new glucosyl esters of all-trans-aritinoic acid were synthesized by the reaction of all-transafitinoic acid with O-acetylglucopyranosyl bromide or O-acetylgalactopyranosyl bromide, O-acetylgalactopyranosyl bromide, O-acetylgalactopyranosyl bromide in the presence of sodium carbonate and Bu4NBr. Their structures were confirmed by IR、^1H NMR and MS.