足月新生儿脐血血清游离卡尼汀浓度及相关因素研究

Free carnitine concentration in cord blood and its affecting factors in full-term neonates

目的了解足月新生儿脐血血清游离卡尼汀浓度及其相关影响因素.方法收集2004年11月至2005年2月出生的足月新生儿89例,男46例,女43例.平均胎龄(39.4±0.9)周,出生体重(3427.2±414.4)g,身长(49.8±2.5)cm,头围(34.8±1.4)cm,Apgar评分为8～10分.平产50例,剖宫产39例.于出生后即采集脐血2 ml,用高效液相(HPLC)法测定脐血血清中卡尼汀浓度.结果 89例正常新生儿平均脐血血清卡尼汀浓度为(52.2±22.9)μmol/L.其中男性组为(49.3±18.7)μmol/L,女性组为(55.3±26.5)μmol/L,两者之间差异无显著性(P=0.216);平产组为(52.4±24.5)μmol/L,剖宫产组为(51.9±20.9)μmol/L,两者之间差异无显著性(P=0.924).根据新生儿出生体重分为＜3000 g(11例)、3000～3999 g(68例)和≥4000 g(10例)3组,其血清卡尼汀平均值分别为(61.5±26.2)μmol/L、(52.0±23.1)μmol/L和(42.8±12.3)μmol/L.脐血卡尼汀浓度与出生体重呈负相关(r=-0.239,P=0.026);与孕母年龄、新生儿胎龄、身长和头围无相关性.结论本组足月新生儿脐血血清卡尼汀浓度为(52.2±22.9)μmol/L,与新生儿出生体重呈负相关,与孕母年龄、新生儿胎龄、身长、头围、性别和分娩方式无相关性.

Objective To determine free carnitine concentration in cord blood and to investigate its affecting factors in full-term neonates. Methods The blood samples were taken from the umbilical cord of 89 newborn infants （male 46 and female 43） with mean gestational age of （39.44±0.9）w. Their mean birth weight, body height and head circumference were （3427.2± 414.4）g, （49.8± 2.5）cm and（34.8±1.4）cm,respectively and Apgar＇ s score was 8-10. The free carnitine concentration in cord blood was determined by HPLC. Results The concentration of free carnitine in all 89 neonates was （52.2 ± 22.9）μmol/L,and（49.3 ± 18.7） μmol/L in 46 males and （55.3± 26.5） μmol/L in 43 females . There was no significant difference between males and females （P = 0.216）. The concentrations of free carnitine in 50 neonates underwent normal delivery were （52.4 ± 24.5）μmol/L and in 39 neonates underwent cesarean section were （51.9± 20.9）μmol/ L,respectively （P = 0. 924）. The infants were divided into 3 groups according to birth weight：less than 3000 g （n = 11）, 3000-3999 g （n = 68） and more than 4000 g（n = 10）, in which the concentration of carnitine were （61.5± 26.2） μmol/L, （52.0± 23.1） μmol/L and （42.8± 12.3） μmol/L, respectively, carnitine concentration had a negative correlation with birth weight （r = - 0. 239, P = 0.026）, but no correlation with mother age, gestational age, body height and head circumference. Conclusions The concentration of the free concentration have a negative correlation with birth weight.