癫痫患者血浆激素水平变化的研究

The Study of the Serum Hormone Concentration Changes in Patients with Epilepsy

目的:(1)了解癫痫患者的血浆激素水平变化情况;(2)眼抗癫痫药物(anti-epilcpsy drugs,AEDs)对于癫痫患者血浆激素水平的影响。方法:用电化学发光法检测入组癫痫患者的泌乳素(prolactin,PRL)、雌二醇(estradiol,E2)、孕酮(progesterone,PG)以及总睾酮 (totol testosterone,TTes)的血浆水平,并分别比较男、女患者未用抗癫痫药物组(NAEDs组)与用药组(AEDs组)的血浆激素水平的变化。结果:(1)入组71例患者,男性32例,女性39例;50．70％(36／71)有PRL水平升高,43 66％(35／71)患者E2水平升高,分别有 18．31％(13／71)和25.35％(18／71)患者的TTes、PG水平下降。(2)女性癫痫患者中,AEDs组患者有77．78％(21／27)出现E2升高。 NAEDs组为41．67％(5／12),两组有显著差异,P<0．05;男性癫痫患者中,AEDs组33．33％(5／15)出现TTes水平下降,NAEDs组为 5．90％(1／17),两组有显著差异。结论:(1)癫痫患者的激素水平有变化;(2)抗癫痫药物可影响激素水平。男女患者的激素受抗癫痫药物的影响变化不同,男性患者的TTes水平降低,女性患者的E2水平升高可能与抗癫痫药物的应用有关。

Objective： 1. To investigate the serum hormone concentrations changes in patients with epilepsy, 2. To evaluate serum hormone changes of the anti-epileptic drugs effects. Methods： All the participants were drawn blood sample for the analysis of serum prolactin （PRL）, estradiol（E2. ）, progesterone（PG） and Totol testosterone（TTes ）. Results： 1. The study was performed in 71 epileptic patients （male 32 female 39）. The levels of PRL and E2 were high in most patients, the radio was 50. 70%（36/71） and 43. 66%（35/71） respectively. The concentrations of PG and TTes were reduced in 18（25. 35%,18/71 ）patients and 13（18.31%, 13/71 ）patients. 2. The incidence of elevation of serum E2 concentration was 77. 78% in women patients with anti-epilepitic drug, meanwhile, 41.67% in those without the treatment, which showed significant differences. TTes were low in 5（33. 33%） men patients with the antiseizure treatment, it is 5.90%（1/17） in patients without treatment, the difference is significant. The varies of PG and PRL between the patients with or without medical treatment showed no differences. Condusions： 1 ）There were changes of the serum hormone concentration in patients with epilepsy. 2）Antiepileptic drug affected the serum hormone concentrations.