C-反应蛋白与血液透析患者营养不良及心血管并发症的关系探讨

The Association among C-reactive Protein, Malnutrition and Cardiovascular Risk in Ure-mic Patients with Hemodialysis

目的:探讨尿毒症血液透析患者C-反应蛋白(CRP)与营养状态及心血管疾病的关系。方法:检测37例尿毒症血液透析患者透析前静脉血CRP、血浆白蛋白(Alb)、转铁蛋白(TRF)及脂蛋白a(Lpa)。根据透析前CRP水平分为正常组(CRP≤5mg／L)和升高组 (CRP>5mg／L)。结果:CRP增高组Alb、TRF明显下降并与CRP呈负相关;Lpa升高,与CRP呈正相关。结论:尿毒症血透患者血清 CRP是炎症反应较好的预测指标,炎症反应在营养不良和心血管疾病中起重要作用。

Objective： To evaluate the association among C-reactive protein（CRP） ,malnutrition and cardiovascular risk in uremic patients with hemodialysis. Methods： Plasma CRP,albumin（Alb）, transferrin（TRF） and appliporteina a（Lp, were measured before hemodialysis in 37 uremic patients. All patients were divided into normal group （CRP≤5mg/L） or abnormal group（CRP〉5mg/L）. Results： Plasma CRP concentration before hemodialysis were negatively correlated with Alb and TRF,and positively correlated with Lpa. Conclusion：CRP can be used as better markers of inflammation in hemodialysis patients. Inflammation plays an important role in malnutrition and cardiovascular disease.