儿童呼吸道感染与肺炎衣原体的关系

Role of Chlamydia Pneumoniae in Paediatric Patients with Respirator Tract Infection and It's Clinical Implication

目的:探讨肺炎衣原体(Cpn)与儿童呼吸道感染之间的关系。方法:用直接免疫荧光(DIF)法检测外周血单核细胞(PBMC)中的Cpn特异性抗原,间接微量免疫荧光(MIF)法检测血浆中Cpn抗体。结果:在40例呼吸道感染患儿PBMC中Cpn特异性抗原阳性率57．5％(23／40),正常儿童28人PBMC中Cpn特异性抗原阳性率32．1％(9／28);P=0．039。血浆中Cpn IgG的阳性检出率分别为 67．5％(27／40)和42．9％(12／28),P=0．043;Cpn IgM的阳性检出率分别为62．5％(25／40)和35．7％(10／28),P=0．030。结论:儿童呼吸道感染与肺炎衣原体有较密切关系。肺炎衣原体的检测可为儿童呼吸道感染诊治提供实验依据。

Objective： To investigate the relationship between Chlamydia pneumoniae （Cpn） and paediatric respiratory-tract infections. Methods： The peripheral blood mononuclear cell （PBMC） specific antigen （Ag） to Cpn was measured by direct immunofluorescence test. Plasma specific antibodies to Cpn （IgG,IgM） were measured by microimmunofluorescence test. Results： 40 patients with respiratory-tract infection and 28 healthy control were＇ enrolled, PBMC Cpn-Ag positive rate was 57. 5%（23/40）for patients and 32. 1%（9/28）for contols （P= 0. 039）,while Plasma Cpn IgG positive rate was 67.5%（27/40）and 42.9%（12/28）,respectively（P=0. 043）;and Cpn-IgM positive rate was 62.5%（25/40）and 35.7%（10/28）,respectively（P=（）. 030）. Conclusion：There was a signiticant correlation between paediatric respiratory-tract infections and Cpn. Detection of Chlamydia pneumoniae can provide the experimental basis of diagnosis and treatment for paediatric respiratory-tract infections.