卡维地罗治疗老年原发性高血压的疗效观察

The Effect of Carvedilol in Essential Hypertension Elderly

目的:探讨卡维地罗治疗老年性高血压的安全性和有效性。方法:随机选择89例老年原发性高血压患者,服用卡维地罗(12．5 -50mg／d),测定临床血压值。结果:服药8周后有效率达83．7％(72／86),收缩压治疗前164．3±21．1mmHg降到治疗后142．4± 16．4mm Hg,舒张压治疗前105．8±12.5 mmHg降到治疗后91．2±8．7 mmHg;心率由治疗前的71．5±6．1次／min到治疗后63．7± 5．6次／min。有3例患者因心动过缓和心悸不适不能耐受而停药,无严重不良反应。结论:卡维地罗治疗老年原发性高血压有较好的疗效和安全性、临床耐受性好。

Objective： To investigate the antihypertensive effect, safety and tolerability of carvedilol on older patients with hypertension, Methods：This is a randomized, open and dose-titration study. With Carvedilol an option to increase the dose from 12.5 nag to 50mg daily after 8 weeks and followed by an open 3-month active treatment period. Blood pressure in observation was made during the period and at the end of the active treatment period. Results： After 12 weeks of administration, blood pressure and the heart rate （HR） declined significantly. Systolic blood pressure declined from 164.3 ± 21.1 mmHg to 142.4 ± 16.4 mm Hg,diastolic blood pressure declined from 105.8 ± 12. 5 to 91.2 ± 8.7 mm Hg （P〈0. 001） ; Heart rate declined from 71.5 ± 6. 1 bpm to 63.7 ± 5.6 bpm（P〈0. 001 ）, No symptoms of adverse reaction were detected. Condusion：Carvedilol is an effective antihypertensive agent that can be used in people with essential hypertension in all age groups, Especially in the older.