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钙神经蛋白结合型免疫抑制剂对糖代谢影响的研究进展

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摘要 环孢素A和FK506应用于器官移植领域,大大地提高了移植物的存活率。但两种药物对胰岛β细胞有直接损害作用,干扰细胞线粒体的能量合成,在转录水平抑制胰岛素合成,减少胰腺组织和血中胰岛素,在转录后水平下调细胞膜胰岛素受体,影响机体糖代谢。
出处 《中华肝胆外科杂志》 CAS CSCD 2005年第12期862-864,共3页 Chinese Journal of Hepatobiliary Surgery
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