系统性红斑狼疮患者T淋巴细胞亚群及NK细胞变化及其临床意义

Clinical Significance of T Cell Subsets and the Expression of NK Cell in Patients with Systemic Lupus Erythematosus

目点研究T淋巴细胞亚群及NK细胞的表达与系统性红斑狼疮(SLE)发病机理的关系。方法根据有无并发狼疮性肾炎分为Ⅰ组、Ⅱ组,采用流式细胞术检测两组SLE患者外周血T淋巴细胞亚群和NK细胞的表达变化。结果与正常对照组比较,SLE患者外周血T淋巴细胞亚群CD3、CD4 T淋巴细胞显著减少,CD8T细胞及NK细胞的表达显著增加,CD4/CD8细胞比值明显下降,尤其在并发狼疮性肾炎组更为显著。结论T淋巴细胞亚群及其NK细胞的表达异常在SLE尤其在狼疮性肾炎的发生、发展过程中发挥着重要作用。

Objective To study the relation between the T Cell Subsets and expression of NK Cell and the pathogenesis of Systemic Lupus Erythematosus（SLE）. Methods Fourty three patients were divided into 2 groups according to patients with or without the Lupus Nephritis. group Ⅰ（ n = 17, non-Lupus Nephritis）, group Ⅱ （n = 26, with Lupus Nephritis）. T Cell Subsets and the expression of NK Cell were determined by whole blood flow cytometry in patients with SLE and the results were compared with that in the controls. Results The results showed that the CD3 ^＋, CD4^ ＋ T cell subsets were significantly decreased, the ratio of CD4/CD8 T cell was reversed, percentage of NK was significantly increased in SLE patients, compared with the normal subjects. The variation of CD3 ^＋, CD4^ ＋ T cell subsets, the percentage of NK cells were even more in SLE with Lupus Nephritis than that in SLE non-Lupus Nephritis. Conclusion T Cell Subsets and expression of NK cells are related to the development of SLE, especially in the case of SLE with Lupus Nephritis.