高血压病患者合并颈动脉粥样硬化与血清高敏C反应蛋白的相关性研究

Serum High-sensitivity C-reactive Protein Level is Associated with Carotid Atherosclerosis in Patients with Essential Hypertension

目的研究合并颈动脉粥样硬化的高血压病患者血清高敏C反应蛋白(hsCRP)的变化,探讨两者之间的相关性。方法对来院就诊的188例原发性高血压患者进行颈动脉超声检查,测量颈总动脉内中膜厚度(IMT)、观察有无颈动脉斑块形成,从而判断有无颈动脉粥样硬化;同时进行血清hsCRP浓度的测定。分析血清hsCRP与颈动脉粥样硬化、颈总动脉内中膜厚度、颈动脉斑块形成之间的关系。结果①合并颈动脉粥样硬化的高血压病患者血清hsCRP显著高于无颈动脉病变者(P<0.01)。②颈总动脉内中膜增厚者血清hsCRP高于颈总动脉内中膜正常者(P<0.05);有颈动脉斑块的患者血清hsCRP明显高于无颈动脉斑块的患者(P<0.01)。结论高血压病合并颈动脉粥样硬化尤其是颈动脉斑块患者的血清hsCRP显著高于无颈动脉病变者,说明血清hsCRP与高血压病患者颈动脉粥样硬化的发生有一定相关性,炎症反应可能参与了高血压病颈动脉粥样硬化的形成。

Objective To study the relationship between serum high-sensitivity C-reactive protein （hsCRP） level and carotid atherosclerosis in patients with essential hypertension. Methods The serum concentrations of high-sensitivity C-reactive protein（hsCRP） were measured in one hundred and eighty-eight patients with essential hypertension. A Color Doppler Ultrasound system was used to investigate the intimal-medial thickness（IMT） of common carotid artery（CCA） and the plaque of carotid artery. Results ①The serum concentrations of hsCRP in the carotid atherosclerosis group were signicantly higher than that in the carotid artery normal group （P 〈 0.01）. ②The serum concentrations of hsCRP in the carotid artery plaque group were signicantly higher than that in the non-carotid artery plaque group （P〈 0.01）. These findings were also present in the group with IMT increasing （P 〈 0.05）. Conclusions Serum high-sensitivity C-reactive protein level is associated with carotid atherosclerosis in patients with essential hypertension. Inflammatory response might play an important role in the pathogenesis of carotid atherosclerosis with essential hypertension.