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PML-RARα融合基因及其诱导特异性免疫应答 被引量：2

PML-RARα Fusion Gene and Its Ability for Specific Immune Response Induction
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摘要 PML-RARα融合基因通过其转录抑制作用而诱发APL已基本得到认可,但其引发APL的机制是错综复杂的,在PML-RARα融合基因的致病过程中,必须有其他因素的共同参与才能导致APL.同时PML-RARα融合蛋白上存在着抗原性,PML-RARα多肽可诱导特异性免疫应答,为免疫治疗的研究提供了可能性.
作者 汤冀 李扬秋
机构地区 暨南大学医学院血液病研究所
出处 《现代临床医学生物工程学杂志》 CAS 2005年第6期469-472,共4页 Journal of Modern Clinical Medical Bioengineering
基金 中德生物技术合作项目(CHN02/319) 广东省科技计划项目(2005B50301016) 广州市科技攻关计划(2003J1-I0011 2005Z1-E4015) 广东省医学科研基金(A2003368)
关键词 PML-RARΑ 急性早幼粒细胞白血病 基因疫苗 克隆性
分类号 R733.7 [医药卫生—肿瘤]
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参考文献18

  • 1Le Beau MM, Bitts S, Davis EM, et al. Recurring chromosomal abnormalities in leukemia in PML- RARA transgenic mice parallel human acute promyelocytic leukemia [ J]. Blood, 2002,99(8) : 2985.
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  • 8Dong S, Stenoien D, Qiu J, et al. Reduced intranuclear mobility of APL fusion proteins accompanies their mislocalization and results in sequestration and decreased mobility of retinoid X receptor[J]. Mol Cell Biol, 2004, 24(10) :4465.
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二级参考文献20

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现代临床医学生物工程学杂志
2005年 第6期

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