原发性系膜增生性肾小球肾炎病变与临床表现关系的研究

A Study on Relationship between Pathologic Change and Clinical Symptoms in Primary Mesangial Proliferative Glomerulonephritis

将８０例肾穿刺活检确诊的原发性系膜增生性肾小球肾炎病变程度分为轻、中、重３级，结合临床表现、肾脏组织学改变及免疫病理，发现临床伴有高血压、反复水肿者病变均较严重；系膜节段性硬化和球囊粘连均见于重度病例；随着病变加重，肾小管萎缩和间质病变发生率增高；系膜区免疫沉积物以ＩｇＭ为主，重症病例ＩｇＭ沉积的发生率比轻、中症者高。

The pathologic change of eighty cases of primary mesangial proliferative glomerulonephritis diagnosed by kidney puncture biopsy are divided into three degrees: light, medium and severity. By analysing clinical symptoms, kidney histopathologic change and immunopathology, the pathologic change of patients accompanied with hypertension and repeated edema clinically are all severe. The mesangial segmental sclerosis and capsular synechia are all happened in severe cases.The rate of renal tubules atrophy and interstitial change are tend to rise with the deteriorating of pathologic change. The immunodeposits IgM are preponderant in mesangium. The rate of IgM deposits are higher in severe cases than in light or medium.