1-(4-苯氧基苯氧基)-2-丙醇的合成及分析

Synthesis and Analysis of 1-(4-Phenoxyphenoxy) Propyl-2-ol

以4-苯氧基苯酚,环氧丙烷为原料合成1-(4-苯氧基苯氧基)-2-丙醇,考察了物料比、反应时间、反应温度等因素对其收率的影响,得到最佳工艺条件。n(4-苯氧基苯酚)：n(环氧丙烷)：n(氢氧化钾)=1：3.0：0.3,反应温度40℃,反应时间3.5h,1-(4-苯氧基苯氧基)-2-丙醇收率最高达93.7％。以液相色谱法,采用LiChrospher 100 RP-18柱、甲醇+水为流动相、紫外检测器、外标法对1-(4-苯氧基苯氧基)-2-丙醇进行了高效液相色谱分析研究。方法标准偏差0.20％,变异系数0.23％,回收率在99.57％～100.52％之间。

1- （4 - phenoxyphenoxy） propyl- 2 -ol was prepared from 4 - phenoxyphenol, and 1,2 - epoxypropane. The effect of reaction temperature, reaction time, dosage of 1,2 - epoxypropane and potassi- um hydrate on 1 - （4 - phenoxyphenoxy） propyl - 2 - ol were investigated. Optimized condition obtained were： n （4 - phenoxyphenol） ： n （1,2 - epoxypropane） ： n （potassium hydrate） = 1：3.0：0.3, temperature：40℃, reaction time： 3.5hrs. The yield of 1 - （4 - phenoxyphenoxy） propyl - 2 - ol can reach 93. 7%. HPLC method was developed for the determination of 1 - （4 - phenoxyphenoxy） propyl - 2 - ol on column LiChrospher 100 RP - 18. The mobile phase was methanol - water （73 ＋ 27）, and samples were detected by UV spectrometry at 230 nm. The recovery was 99.57% -100.52%. The product was characterized by IR, 1H NMR.