牡蛎提取物对高血糖小鼠保护作用

Protective effects of oyster extract on high blood sugar in mice

目的探讨牡蛎提取物对四氧嘧啶诱发的小鼠高血糖的保护作用。方法预先给小鼠牡蛎提取物灌胃,连续4周,然后腹腔注射四氧嘧啶,观察牡蛎提取物对小鼠血糖、体重、胸腺、脾脏重量的影响。结果牡蛎提取物可显著减低由四氧嘧啶所致的小鼠血糖升高的幅度(P<0.01),增加小鼠免疫器官的重量(P<0.05);对正常小鼠血糖无明显影响。结论牡蛎提取物对四氧嘧啶所致小鼠血糖升高有显著的保护作用。

Objective To study the protective effects of oyster extract on high blood sugar model induced by alloxan in mice. Methods The mice were given with oyster extract for 4 weeks successively and then allxan were administered by adbominal cavity inject. Blood sugar level, body weight, chest gland and spleen weight were evaluated. Results Oyster extract markedly lower the increasing of blood sugar（ P 〈 0.01 ）and could increase the immune organ weight（ P 〈 0.05）significantly in allxan induce mice. Oyster extract had on influence on the blood sugar level in control group. Conclusion The oyster extract has a significantly protective effect on increasing of blood glucose in model mice induced by alloxan.