特发性血小板减少性紫癜患者血小板相关抗体及网织血小板检测的临床意义

The clinical significance of the detection of platelet associated antibodies and reticulated platelets in patients with idiopathic thrombocytopenic purpura

目的探讨血小板相关抗体(PAIgG)和网织血小板(RP)检测在特发性血小板减少性紫癜(ITP)治疗中的临床意义。方法收集常州市第一人民医院2003-06～2004-10住院的ITP患者48例,根据疗效分为两组,其中临床有效组40例,临床无效组8例,以50例健康人为正常对照。应用流式细胞仪(FCM)测定其治疗前后血浆和(或)血清PAIgG及RP%,并常规血小板计数。结果ITP患者临床有效组治疗后较治疗前血小板计数明显升高、PAIgG和RP%显著降低(P<0.01)。临床无效组治疗前后血小板计数、PAIgG和RP均无明显变化(P>0.05)。两组治疗前3项指标与对照组比较差异有显著性意义(P<0.01)。结论PAIgG和RP动态检测将是ITP患者血小板治疗效果的预测指标之一。

Objective To study the clinical significance of platelet associated antibodies （PAIgG） and reticulated platelet （RP） in treatment on idiopathic thrombocytopenic purpura （ITP） . Methods A total of 48 idiopathic thrombocytopenic purpura patients and 50 normal people were included. Boold platelet count （BPC）, PAIgG, and percentage of reticulated platelet （RP%） were measured by FCM in 48 patients with ITP and 50 normal people as a control group. Results BPC was increased remarkably, PAIgG and RP% were decreased significantly in ITP patients than that in controls （P 〈 0.01 ） . After effective treatment, BPC , PAIgG and RP% turned to normal level. Conclusion Autoimmune function played an important role in the pathogenesis of ITP. The measurement of PAIgG and RP% was one of important indexes to predict clinical effect on ITP after treatment.