体外循环全身热灌注疗法治疗恶性肿瘤81例报告

The treatment of 81 cases of Advanced malignant tumor with Extracorporeal Whole Body Hyperthermia.

目的 对体外循环全身热灌注疗法（EWBH）治疗恶性肿瘤的疗效及其时机体的损伤情况作一初步分析。方法 2001—2003年中山大学附属第一医院采用EWBH治疗各类型晚期恶性肿瘤病人88例次，通过追踪分析，初步评估该疗法的疗效。通过术前后动态检测病人的血液、脑、肝、肾、肺等脏器功能指标的变化，结合辅助动物实验，分析该疗法对全身各重要器官组织的损伤情况。结果 （1）EWBH治疗晚期恶性肿瘤病人的有效率（CR4-PR）为72．8％，血液相关肿瘤指标下降率为74．4％，肿瘤疼痛缓解率100％。存活期〉1年的65．4％，〉半年的84．0％。（2）该方法对各重要器官的组织和功能可造成一定的轻微和可逆的损伤。结论 EWBH能改善晚期恶性肿瘤病人的预后，提高生存质量，延长存活时间。同时会造成病人各器官组织一定程度的可逆性损害。

Objective This article is mainly to evaluate the primary treatment effect and the impairment of the vital organs and tissues in vivo of the Extracorporeal Whole Body Hyperthermia（EWBH）. Methods From 2001 to 2003,81 cases of advanced malignant tumor were treated with EWBH. It was assayed that the primary treatment effect of the EWBH by following the patients condition. The impair of vital organs and tissues, such as brain, liver, kidney and lung were evaluated by examinating index of blood elements,and by the result of the animal experiment. Results （ 1 ） The effective rate （CR plus PR）of the EWBH was 72. 8% on treating advanced malignant tumor. The descent rate of index concerning tumor（as AFP,CEA etc. ） was 74.4% ,and the rate of pain relieve was 100%. And 65.4% cases alive were over one year and 84% over half one year. （2） There are some impairment on function and tissues in the vital organs but the damage is venial and reversible. Conclusion In treating malignant tumour,EWBH can improve the patients live quality and prolonging their life. EWBH can make some reversible impair to the vital organs and tissues.