化脓性肉芽肿32例临床病理分析

Pyogenic Granuloma : a Clinicopathologic Study of 32 Cases

目的：探讨化脓性肉芽肿（pyogenic granuloma，PG）的临床病理特点及鉴别诊断。方法：32例PG行常规检查，其中8例标本行免疫组化检查，并对18例进行了随访。结果：32例PG病人年龄13—66岁，平均36岁；男10例，女22例；病变位于头面部25例；肿瘤平均1cm大小；26例病变呈息肉状；肿瘤位于皮肤或粘膜内，由增生的毛细血管形成分叶状结构；血管内皮细胞CD34（＋），血管周梭形细胞SMA（＋）；3例（16．7％）复发。结论：PG在年龄、性别、发病部位及病程上有明显特点，少数可复发。肿瘤主要由内皮细胞和血管周梭形细胞组成，其主要特征是毛细血管瘤样增生形成小叶结构。

Objective：To investigate the clinicopathologic features and differential diagnosis of the pyogenic granuloma （PG）. Methods： 32 cases of PG were studied by routine stain and 8 of them also by immunohistochemistry ,18 patients were followed up. Results： Range of age in 32 patients with PG was from 13 to 66 years old （mean36）, with 10 male and 22 female. Location of the tumor was in the head and face （25 cases）. The tumors were with mean size of 1 cm.The lesions showed polypoid shape in 26 cases. The tumors composed of lobular structure consisted of proliferating capillaries in mucosa and derma. Immunohistochemically, endothehal cells expressed CD34 and peri- vascular spindle cells showed SMA positive. The recurrent rate in 3 cases was16.7%. Conclusions：PG has evident charateristics in age, sex, site and lesion duration. Few cases can recur.The important elements of the tumors are endothelial cells and the peri- vascular spindle cells and the chief feature is lobular structure composed of proliferating capillaries.