生长抑素关节腔内注射治疗膝关节骨性关节炎的疗效观察

Clinical study on the treatment of knee osteoarthritis with somatostatin injected intra-articularly

目的探讨生长抑素治疗膝关节骨性关节炎的疗效。方法对30例膝关节骨性关节炎患者进行关节腔内注射生长抑素750μg,每周1次,连续6周。记录治疗前后患者的VAS疼痛评分及治疗后发生的副作用,并采用林志雄评分标准评价治疗效果。结果治疗后患者疼痛明显减轻,关节综合评分优良率显著提高,没有发生严重副作用。结论生长抑素关节腔内注射治疗膝关节骨性关节炎疗效确切,副作用少,是治疗膝关节骨性关节炎的理想方法。

Objective To evaluate the therapeutic efficacy of somatostatin（SST） injected intra- articularly in the treatmere of knee osteoarthritis. Methods Twenty patients with knee osteoarthritis were treated with SST intra - articular injection. The treatment consisted of 6 injections administered weekly with 750 μg of SST. Visual analogue scales（VAS） before and after treatment as well as side effects were recorded, Ppatients were also evaluated by Linzhixiong＇s knee functional scales. Results The patients had improvements in pain and in Linzhixiong＇ s knee functional scales after intra- articular SST. There were no severn side effects happened. Condusion Intraarticular injection of SST satisfactorily benefits the patients with knee osteoarthritis without any severe side effect. It is an ideal treatment for knee osteoarthritis.