高甘油三酯血症与急性胰腺炎

Hypertriglyceridemia and acute pancreatitis

目的探讨高甘油三酯血症与急性胰腺炎(AP)的关系。方法血清甘油三酯(TG)≥11.3mmol/L的AP15例(Ⅰ组);TG<11.3mmol/L的AP29例(Ⅱ组)。对两组的Ranson积分、并发症发生率进行比较,并对TG值和Ranson积分进行相关分析。结果Ⅰ组与Ⅱ组相比,Ranson积分、并发症发生率均显著性增高(均P<0.05)。44例患者的TG值和Ranson积分之间存在直线相关(P<0.01),Ⅰ组TG值和Ranson积分之间存在直线相关关系(P<0.01),该组中9例胆源性病例也存在直线相关关系(P<0.01);Ⅱ组TG值和Ranson积分之间无直线相关关系(P>0.05),其中20例胆源性病例无直线相关关系(P>0.05)。结论高甘油三酯血症与AP的关系密切,血清甘油三酯水平与AP的病变程度呈正相关,合并高甘油三酯血症的AP患者并发症的发生率有明显的增高。

Objective To evaluate the relationship between hypertriglyceridemia and acute pancreatitis. Methods Serum triglyceride （ TG ） level was ≥ 11.3 mmol/L in 15 cases （ group Ⅰ） and was 〈 11.3 mmol/L in 29 cases （ group Ⅱ ）. Ranson score and complication incidence were compared between the two groups. The correlation between TG and Ranson score was analyzed. Results Ranson score and complication incidence were significandy increased in group I as compared with group Ⅱ （ P 〈 0.05 ）. TG was linearly correlated with Ranson score in 44 patients （P〈0.01）,which was the case in group Ⅰ （P〈0.01） and in 9 cases of biliary diseases in group I （P 〈0.01 ） ,but there was no linear correlation between Ranson score and TG level in group Ⅱ and between 20 cases of bliliary diseases in group Ⅱ（ P 〉 0.05 for each ）. Conclusion There is a close relationship between hypertriglyceridemia and acute pancreatitis. Serum TG is positively correlated with the degree of acute pancreatitis. The acute pancreatitis patients have increased incidence of hypertriglyceridemia.