吸入性糖皮质激素对哮喘气道重塑模型平滑肌的影响

The effects of inhaled corticosteroids on airway smooth muscles in asthmatic remodeling model

目的探讨吸入性糖皮质激素对哮喘气道重塑模型平滑肌的影响。方法雄性豚鼠108只,随机分为哮喘发作组(A组)、治疗组(B组)和对照组(C组)。每组动物分别予以卵蛋白(OVA)、布地奈德或生理盐水处理,在每个时点末次激发后24 h处死,留取肺组织,测量气道平滑肌的厚度。结果在12周时各组气道平滑肌层厚度,A组(26.56±3.39)μm,B组(18.29±4.11)μm,C组(9.85±3.59)μm,两两比较均有显著性差异(P<0.05)。在首次激发后24 h各组气道平滑肌层厚度分别为(7.66±1.86)μm、(7.81±1.61)μm和(7.79±1.55)μm,两两比较均无显著性差异(P>0.05),直到激发8周后各组平滑肌层厚度才出现显著性差异(P<0.05)。结论吸入性糖皮质激素能抑制气道平滑肌层增厚,但这种作用是不完全的。

Objective To investigate the effects of inhaled corticosteroids（ICS）on airway muscles of asthmatic remodeling model. Methods One hundred and eight guinea pigs were divided into three groups randomly and equally：asthmatic group（A）, therapeutic group（B）, and control group（C）. Group A,B and C were treated by ovalbumin, hudesonide,or normal saline respectively. The lung tissue specimens were collected after the guinea pigs were killed, and the thickness of airway smooth muscle was determined. Results The thickness of airway smooth muscle in group A, B and C was （26.56±3.39）μm, （18. 29±4.11 ）μm,and （9.85±3.59）μm respectively at 12 weeks. Conclusion ICS,to some extent, can prevent the airway smooth muscle from thickening in asthmatic remodeling model.