榄香烯静脉输注浓缩液对G422小鼠神经胶质瘤疗效的实验研究

Effect of concentrated elemene injection on mouse G422 glioma in vivo

目的测定榄香烯静脉输注浓缩液小鼠体内实验抗肿瘤疗效。方法用Cremophor EL作增溶剂配合丙二醇制成2％榄香烯静脉输注浓缩液。以静脉注射（40、20、10mg/kg）或腹腔注射（80、60、40mg／kg）途径给药，静脉给药组每天2次，腹腔给药组每天1次，连续给药5d进行榄香烯注射液动物脑瘤G422（颅内接种）模型抗肿瘤疗效实验。结果榄香烯静脉输注浓缩液体内对动物脑瘤G422（颅内接种）模型肿瘤生命延长率为：静脉给药方案：高剂量组为56．07％～59．16％，中剂量组为45．55％～47．98％，低剂量组为31．25％～38．22％，生命延长率比较明显；腹腔给药方案：高剂量组为12．0％～24．0％，中剂量组35．1％～37．0％，低剂量组为30．9％～36．1％。若以静脉给药80mg／kg，每天1次，连续10d给药，结果显示其生命延长率为52．60％～57．07％。结论榄香烯静脉输注浓缩液对小鼠神经胶质瘤G422（颅内接种）模型有一定的抑制作用。

Objective To evaluate the anti-tumor effect of concentrated elemene injection（CEI） on mouse G422 glioma cells in vivo. Methods Elemene, cremophor EL and propylene glycol were mad into 2 % CEI. The mouse glioma model was developed by encephalic inoculation. The mouse model received twice daily i. v. injections of vehicle or CEI （40,20,10 mg/kg body weight for different groups） for 5 days;or received once daily i. p. injections of vehicle or CEI （80,60,40 mg/kg body weight for different groups） for 5 days. Results CEI could inhibit the glioma. The inhibition rates were 56.07% -59.16% ,45.55%-47.98% and 31.25%-38.22% respectively in i. v. groups,and 12.0%-24.0 %, 35.1% - 37.0 % and 30.9 % - 36.1% respectively in i. p. groups. If 80 mg/kg was administered once daily for 10 days, the inhibition rate was 52.60% -57.07 %. Conclusion Concentrated elemene injection inhibited proliferation of mice G422 glioma model.