蛋白质组学在阿尔采末病中的研究进展

The Progress in Proteomics Researches of Alzheimer' s Disease

蛋白质组学是基因组时代产生的一门重要学科,是从整体水平对蛋白质的综合分析。阿尔采末病(A lzheimer's d isease,AD)是常见而复杂的神经退行性疾病之一。应用蛋白质组学对AD进行研究,不仅可在蛋白质水平上揭示疾病的本质,还有助于全面探讨AD的病理机制,建立诊断标准,发现药物治疗靶点。本文从病理机制(特别是蛋白质翻译后修饰)、发现临床生物标签及治疗药物三个方面,对蛋白质组学在AD中的研究进展进行了综述。

Proteomics , an important discipline in genomic era , is the integrated study of protein properties on a large scale. Application of proteomics researches in Alzheimer＇s ,disease （ AD）, which is one of most common and complex neurodegeneration disorders, we can not only elucidate the essential issues of disease in protein level, but give a whole view in the pathological mechanisms identification, diagnosis and therapeutic targets discovery as well. The three aspects about the progresses in proteomics researches of AD were reviewed in this article.