针灸保护胃黏膜与热休克蛋白的关系

Relationship between the protection of acupuncture and moxibustion on gastric mucosa and heat shock protein

目的从多方面探讨针灸治疗保护胃黏膜是否与热休克蛋白的诱导有关。资料来源应用计算机检索M edline1985-01/2004-12和Em base1985-01/2004-12有关针灸、胃黏膜保护和热休克蛋白的文献,检索词“Acupuncture,m oxibustion,gastric m ucosa protection,heat shockproteins”,并限定文章语言种类为English。同时计算机检索CBM、CBM disc系统、万方数据库1993-01/2004-12有关针灸、胃黏膜保护和热休克蛋白的文献,限定文章语言种类为中文,检索词“针刺、艾灸、胃黏膜保护、胃黏膜损伤、热休克蛋白”。资料选择选取有关热休克蛋白与胃黏膜损伤、针灸疗法内在联系的相关文献,查找余下文献全文,进一步判断是否明确指出以上三者之间的密切联系。纳入标准①热休克蛋白对胃黏膜有一定的保护作用。②针灸疗法能诱导热休克蛋白的产生。③针灸疗法在临床和实验两方面的胃黏膜保护作用。④临床观察和实验都符合随机标准。排除标准明显不符合随机标准,无平行对照。资料提炼共检索到57篇关于针灸疗法、热休克蛋白、胃黏膜损伤的实验及临床研究文章,17篇符合纳入标准。排除的40篇文献中,18篇因结论与本文关系不够密切;11篇因结论重复性大,无引用意义;11篇为综述,无直接引用价值。资料综合17篇文献分别对针灸疗法与胃黏膜保护、热休克蛋白的紧密联系做以比较分析。结论针灸与胃黏膜保护、热休克蛋白都有密切联系,从理论上可推断出针灸保护胃黏膜与热休克蛋白的诱导是分不开的,值得在这方面进行深入探讨。

OBJECTIVE： Whether or not protecting gastric mucosa by acupuncture and moxibustion is related with the induction of heat shock protein was discussed in various ways. DATA SOURCES： A computer-based online search of Medline database and Emase was undertaken to identify articles about acupuncture and moxibustion, protection of gastric mucosa and heat shock protein published in English from January 1985 to December 2004 by using the keywords of ＂acupuncture, moxibustion, gastric mucosa protection, heat shock proteins＂. Meanwhile, Chinese articles about acupuncture and moxibustion, protection of gastric rnucosa and heat shock protein published between January 1993 and December 2004 were searched in CBM, CBMdisc systems and Wanfang database, the keywords were ＂acupuncture, moxibustion, gastric mucosa protection, heat shock proteins＂ in Chinese. STUDY SELECTION： The literatures indicating the internal relationship among acupuncture and moxibustion, gastric mucosa＇s protection and heat shock proteins were chosen. Then the remainder was searched further to confirm whether indicating the above relationship. Inclusive criteria： （1） Heat shock proteins had the effects in protecting gastric mucosa. （2） Acupuncture and moxibustion therapy could induce heat shock proteins. （3） Acupuncture and moxibustion therapy had the effects in protecting gastric mucosa both in experiment and clinic. （4） The clinic observations and experiments accorded with random principle. Exclusive criteria： The literatures did not accord with random and parallel comparison principle obviously. DATA EXTRACTION： Fifty-seven literatures about acupuncture and moxibustion, protection of gastric mucosa and heat shock proteins in clinic and experiment were obtained, and 17 of them accorded with the inclusive criteria. Of the 40 literatures being excluded, 18 were not closely related with this article, 11 had the same conclusion, and 11 were summarization which had no value of direct citation, DATA SYNTHESIS： The relationships of acupuncture and moxibustion with the protectioh of gastric mucosa and heat shock proteins were compared and analyzed in the 17 articles. CONCLUSION： Acupuncture and moxibustion therapy has close relationship with both the protection of gastric mucosa and heat shock proteins. So it could be deduced that the effect of acupuncture and moxibustion in protecting gastric mucosa is not separated from the inducement of heat shock proteins. It is very significant to explore this aspect.