舒利通颗粒药效学作用的实验研究

A Study on Pharmacological Effects of Shulitong Granules

目的通过动物实验,研究舒利通颗粒治疗慢性前列腺炎的药效学作用。方法采用醋酸引起小鼠疼痛而扭体的实验,观察舒利通颗粒的镇痛作用;通过二甲苯致炎剂所致小鼠耳廓肿胀和大鼠棉球肉芽肿形成实验,观察该药对急慢性炎症的抗炎作用。结果舒利通颗粒对小鼠醋酸扭体反应次数有显著性降低作用(P<0.01),对二甲苯的致炎作用有显著性减轻作用(P<0.05),对大鼠棉球肉芽肿形成有明显的抑制作用(P<0.01)。结论舒利通颗粒有很好的药效学作用,具有明显的镇痛作用和抗炎作用,提示该药对慢性前列腺炎有较好的治疗效果。

Objective To investigate the pharmacological effects of Shulitong granules, a new preparation for chronic prostatitis in our hospital. Methods Body twisting method was used to study the analgesic effect of Shulitong granules on mouse models. Xylene and cotton ball were employed to investigate the anti-inflammatory effect of the granules on inflammation of the auricles of mice and chronic inflammation of rats. Results Shulitong granules could reduce the number oi times of body twisting due to pain caused by acetic acid,inhibit the swelling of the mice auricle induced by xylene and suppress the granuloma formation of rats caused by cotton ball. There was a marked difference between the therapeutic group and the control group. Conclusion The drug has a good therapeutic effect and possesses significant analgesic and anti-inflammatory effects, thus has potential for treatment of chronic prostatitis in humans.