孕妇血浆及血清中胎儿游离DNA的研究进展

Advancement in Research on Cell-free Fetal DNA in Maternal Plasma

无创伤性产前诊断是近年来人们关注的热点,孕妇血浆及血清中胎儿游离DNA的存在,为无创伤性产前诊断开辟了新的途径。本文介绍了胎儿游离DNA的来源、生物学特点及在产前诊断中的应用,胎儿游离DNA具有含量高且产后很快清除等优点,有广泛的临床应用价值。

The existence of circulating fetal DNA in plasma ot pregnant women provides a possibility for no risk and non-invasive prenatal diagnosis and its detection exhibits broad clinical application value. In the article, we introduced locally the origin of circulating fetal DNA, its fundamental characteristics and application of detection for it in prenatal diagnosis.