慢性肝病患者血浆瘦素水平变化及临床意义

THE CHANGE OF PLASMA LEPTIN LEVELS AND ITS CLINICAL SIGNIFICANCE IN PATIENTS WITH CHRONIC LIVER DISEASE

目的探讨慢性肝病患者血浆瘦素(Leptin)水平的变化及其临床意义。方法选择男性慢性肝炎、脂肪肝、肝硬化患者及正常男性对照各25例,分别测量其身高、体重,计算体重指数(BMI)、腰围/臀围比(WHR);血浆Leptin水平采用ELISA的方法测定,比较各慢性肝病组与对照组及慢性肝病不同病因亚组血浆Leptin水平的变化。结果肝炎组、脂肪肝组、肝硬化组血浆Leptin水平均明显高于对照组;且血浆瘦素水平与肝功能分级相关。结论慢性肝病患者血浆Leptin水平升高,Leptin可能参与了慢性肝病病理生理过程。

Objective To determine the change of plasma leptin levels and its clinical significance in patients with chronic liver disease. Methods 25 patients with chronic hepatitis,25 patients with fatty liver,25 patients with cirihosis of liver and 25 normal persons were admitted to the investigations. The height and weight of the candidates were measured simultaneously, body mass index （BMI） and waist/hip ratio（WHR） were calculated. The level of plasma leptin was measured by ELISA. Results We found that the level of leptin groups from hepatitis, fatty liver groups and Cirrhosis of liver group was significantly higher than that of the control groups; there is no difference among three experiment groups, but there is correlation between the level of leptin and the stratification of the liver function. Conclusion The plasma leptin level were raised and correlated with disease severity in patients with chronic liver disease. The leptin may play a role in the pathophysiology of chronic liver disease.