葛根素对梗阻性黄疸患者肾功能的保护作用观察

Protective effect of Puerarin on renal function of patients with obstructive jaundice

目的观察葛根素对梗阻性黄疸(O J)患者肾功能的保护作用。方法O J伴肾功能损害患者56例,随机分为术后常规处理组(A组)和葛根素防治组(B组)各28例。另选28例无黄疸的需要手术治疗的肝胆疾病患者为对照组(C组)。观察术前及术后各组血浆内皮素(ET)及肾功能指标的变化。结果肌酐清除率(Cor)与ET呈负相关(r=-0.80,P<0.01)。与术前1d相比,术后第7天,B组ET显著降低(P<0.05),肌酐清除率(C cr)显著升高(P<0.01);A组手术前、后两指标差异无显著性(P均>0.05)。术后7d,A、B两组ET、C cr差异显著(P均<0.05)。结论葛根素可降低O J患者的血浆ET含量,改善肾脏组织的血液灌流量,对肾功能损害有一定的防治作用。

Objective： To study the effect of Puerain protection on renal in patients with obstructive jaundice （OJ）. Methods： 56 patients of renal injury with OJ were randomly divided into 2 groups, 28 patients each. Group A were gave common manegement post-operatively,while group B were gave Puerarin. Meanwhile, 28 cases of non-jaundice patients who had hepatic or biliary diseases and also needed operations were compared as control group （group C）. The levels of plsma endotheliotoxin （ET） and renal function in each group were observed pre and post operation. Results： creatinine clearance rate（Ccr） had a significantly negative relationship with ET（ r = -0. 80, P〈0.01）. Compared with the level in first day pre-operative,the ET level in group B was significantly decreased （ P 〈0.05） together with the Ccr level was significantly increased （ P 〈0. 01） in the seventh day post operative. The changings of ET and Ccr levels in group A were not significant. In the seventh day post-operative the ET and Ccr levels were significantly different between group A and B. Conclusion： The Puerarin might resist renal injury by decreasing the blood ET level and increasing the renal perfusion.