华法令和阿斯匹林预防心房颤动并发血栓栓塞的比较研究

Comparative study of the effect of warfarin with aspirin on preventing atrial fibrillation from thrombo-embolism

目的探讨心房颤动患者抗凝治疗的重要性,以降低血栓栓塞事件的发生率.方法对2001年5月-2003年11月在我院治疗的132例房颤患者,给予口服阿司匹林治疗的69例,口服华法令治疗的63例.对两组患者随访1年的血栓栓塞事件发生率进行对比分析.结果经用华法令抗凝,INR达到2.0～3.0后,其血栓栓塞事件发生率较服用阿司匹林治疗明显下降.抗凝治疗者出现1例上消化道出血(P＜0.01),无出血性死亡病例.结论华法令对降低心房颤动所致血栓栓塞性事件发生率有效,是提高心房颤动患者的生存率的有效治疗措施之一.

Objective： To investigate the importance of anticoagulant treatment for patients who suffered from atrial fibrillation and reduce the incidence rate of thrombo-embolism. Methods： Among those 132 cases with atrial fibrillation who were treated in our hospital from May 2001 to November 2003, 69 cases had been treated by taking aspirin orally and 63 cases by warfarin. Then all patients were followed up in one year and the incidence rates of thrombo-embolism were analyzed between these two groups. Results： The incidence rate of thrombo-embolism obviously decrease by anticoagulation with warfarin than that by anticoagulation with aspirin in patients whose INR reaches 2.0 - 3.0. Among anticongulation patients, only one case was complicated with hemorrhage of upper digestive tract and no case died from hemorrhage among patients by anticoagulation with warfarin. Conclusion： Warfarin is effective to reduce the incidence of thrombo-embolism induced by atrial fibrillation. It is one of the effective therapies to improve the survival rate of atrial fibrillation sufferers.