海马内微量注射褪黑素的免疫调节作用

Immunomodulatory effects of melatonin microinjected into hippocampus in rats

研究褪黑素（ＭＴ）经海马对大鼠免疫系统的影响。微量注射ＭＴ１μｇ至双侧海马，可显著地增强脾淋巴细胞ＣｏｎＡ诱导的增殖反应，其量效曲线呈钟罩形。连续３ｄ注射ＭＴ，能明显提高脾细胞产生ＩＬ－２和腹腔巨噬细胞产生ＩＬ－１，还能增强ＮＫ细胞活性。提示，ＭＴ能通过海马调节免疫功能。

Immunomodulatory effects of melatonin microinjected into hippocampus were studied. The results showed that splenocyte proliferative responses to ConA were enhanced significantly after melatonin(0.25～2μg) microinjected into bilateral hippocampus.Dose-response curve of melationin on the splenocyte proliferation was bell-shaped.In rats with melatonin(1μg) microinjected into their hippocampus, enhanced IL-2,elevated activity of nature kill cells and promoted IL-1 were observed. The results suggest that melatonin might modulate immunologic functions via hippocampus.