摘要
采用缩窄腹主动脉下段的方法造成家兔实验性妊高征模型,并采用比浊法和发色底物分解产色法检测了注射青心酮(3,4-Dihydroxyacetophenone,DHAP)的模型兔血小板聚集性(PAg)、血浆组织型纤溶酶原激活物(tPA)及其抑制物(PAI-1)活性。结果显示DHAP可显著降低模型兔PAg;对血浆PAI-1活性的抑制作用明显强于对tPA的作用,因此,DHAP对血小板功能和血纤溶活性的作用可能是其改善子宫胎盘血循环的作用机制之一。
An animal model for pregnancyinduced hypertension(PIH) was produced in pregnant rabbits by constricting the aorta below the renal arteries and the effects of 3,4-Dihydroxyacetophenone(DHAP)on the activity of tPA and PAI-1 and blood platelet aggregation (PAg) were investigated by spedal substrata decomposition method and Born's method respectively. The results showed that the PAg of the rabbits decreased significantly by DHAP,the inhibitory effect on tPA activity was stronger than that on PAI-1. Therefore, the effects of DHAP on platelet function and the blood fibrinolysis might be the important mechanism in the improvement of utero-placental circulation by DHAP.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第3期244-246,共3页
Chinese Pharmacological Bulletin