期刊文献+

蛇毒神经毒素的镇痛作用 被引量:6

原文传递
导出
摘要 早在二十世纪初,人们就开始应用蛇毒来缓解恶性肿瘤疼痛、神经痛和关节痛。1933年Calmette及Taguet先后发现肌肉注射微量眼镜蛇毒具有类似吗啡样的中枢性镇痛作用。此后Macht和Steinbrocker等不少学者也相继报告了类似的结果。之后,其它含有神经毒素的蛇毒也先后被发现具有镇痛作用,人们从蛇毒中分离出神经毒素(neurotoxin,NT)作为镇痛药物。
出处 《福州总医院学报》 2005年第4期355-357,354,共4页 Journal of Fuzhou General Hospital
  • 相关文献

参考文献11

二级参考文献24

  • 1方园,韩济生.脑内发现全新的阿片受体样受体及其内源性配体[J].生理科学进展,1996,27(3):210-214. 被引量:8
  • 2韩济生 任民峰 等.中枢神经介质概论(第2版)[M].北京:科学技术出版社,1980.268-331.
  • 3于龙川 韩济生.中脑边缘镇痛回路的研究[J].生理科学,1986,6(4):320-320.
  • 4[1]Spande TF, Garraffo HM, Edwards MW, et al. Epibatidine: a novel (chloropyridyl) azabicycloheptane with potent analgesic acitivity from an Ecuadoran frog. J Am Chem Soc,1992, 114:3475~3478.
  • 5[2]Badio B, Daly JW. Epibatidine, a potent analgetic and nicotinic agonist. Mol Pharmacol, 1994, 45:563 ~569.
  • 6[3]Sullivvan JP, Decker MW, Brioni JD, et al. ( +/- )-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors. J Pharmacol Exp Ther, 1994, 271: 624~631.
  • 7[4]Bannon AW, Gunther KL, Decker MW. Is epibatidine really analgesic? Dissociation of the activity, temperature, and analgesic effects of ( + )-epibatidine. Pharmacol Biochem Behav, 1995, 51 : 693 ~698.
  • 8[5]Donnelly-Roberts DL, Putffarcken PS, Kuntzweiler TA, et al. ABT-594 [ ( R ) -5-( 2-azetidinylmethoxy ) -2-chloropyridine ] :A novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors:I In vitro characterization. J Pharmacol Exp Ther, 1998, 285: 777 ~ 786.
  • 9[6]Meyer MD, Decker MW, Rueter LE, et al. The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain. Eur J Pharmacol, 2000, 393: 171 ~177.
  • 10[7]Bannon AW, Decker MW, Holladay MW, et al. Broadspectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors. Science,1998, 279: 77 ~81.

共引文献18

同被引文献85

引证文献6

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部