中药组方作为血管栓塞剂栓塞肝动脉的实验研究

THE EXPERIMENTAL STUDIES OF CHINESE MEDICINAL HERBS AS A VASCULAR EMBOLIZATION AGENT EMBOLIZING THE HEPATIC ARTERIES

目的:研究中药组方作为血管栓塞剂的有效性、安全性及相关特性,以期获得一种理想的肿瘤血管栓塞剂。方法:根据药典提供的数味具有抗癌和促凝作用的中草药将其制备成栓塞剂。对其进行一系列有关特性的研究和鉴定,并应用其进行8头健康猪的肝动脉栓塞实验。结果:中药组方栓塞剂为一种混县剂,有一定粘滞性,不透X线,易经各种介入用导管注射;该栓塞剂具有良好的血液相容性和组织相容性,无致热原性及毒性作用;栓塞部位主要是末梢小动脉,栓塞牢靠,维持时间可达5周,不易形成侧枝循环;经光镜和电镜观察其对正常肝组织损伤轻微,仅出现栓塞部位的肝细胞水变性和臆浆灶性坏死。结论:中药组方检塞剂具有良好的血管栓塞作用,使用方便、安全,是一种较理想的末梢型血管栓塞剂。

Objective： To study the efficacy, safety and correlative charaeterlstics of Chinese medicinal herb as a vascular embolization agent. Method.. We manufactured the combination as a vascular embolization agent from several kinds of Chinese medicinal herb which served as anticarcinogen and coagulatnt according to the Chinese Pharmacopeia. We studied the characteristics of the combination through embolizing the hepatic arterial in eight pigs with it. Results： The combination was a non- homogenous suspended matter. It was easily injected through 5 - F catheter and hyper attenuating under fluoroscopy, meanwhile, with good histocompatibility and hemo- compatibility, without pyrogenetic response and toxicity. The combination mainly embolized peripheral arterim, maintaining occlusionfor 5 weeks and without formation of collateral circulation. We found the injuries of normal hepatic tissues were alight hepatic cytonecrosis and endochyloma focal necrosis through optical and electronic microscope. Conclusion： The Chinese medicinal herb combination is safe and effective in use with angioembolic function and a potential peripheral emboization agent.