老年高血压合并腔隙性脑梗塞患者胰岛素抵抗的临床观察

A CLINICAL STUDY ON THE RELATIONSHIP BETWEEN INSULIN RESISTANCE AND LACUNAR CELEBRAL INFARCTION WITH ELDERLY HYPERTENSION PATIENTS

目的:研究胰岛素抵抗(IR)与高血压合并腔隙性脑梗塞患者之间的关系。方法:选取28例高血压合并腔隙性脑梗塞患者作为研究对象,测定血糖(FPG)、胰岛素水平(FINS)、C-肽、总胆固醇(CH)、甘油三脂(TG)。另28例正常健康老年人作为对照组,同时采用李光伟等提出的胰岛素敏感指效(ISI)方法进行IR计算。结果:高血压合并腔隙性脑梗塞患者FINS、C-肽水平显著高于对照组(p<0.01),其ISI较对照组显著降低(P<0.01)、脑梗死组FINS显著高于正常对照组(P<0.05),其ISI较正常对照组显著降低(p<0.05)。结论:老年高血压合并腔隙性脑梗塞患者存在IR,IR作为腔隙性脑梗塞独立危险因素应引起高度重视。

Objective： To study the relationship between insulin resistance （IR） and lacunar cerebral infarction with elderly hypertersion patients. Method： 56 patients were divided with two groups, 28 eases with lacunar infarction groups, the other 28 cases were normal controis. Their fasting plasma glucoses, serum c-Ps, insluin levels, eholesteral and triglyeeride before breskfast were measured. Their insulin sensitivity indexs （ISI） were compared with each other. Results： FINS, C- Ps were signsificantly higher and ISI was significantly lower in patients with lacunar cerebral infarction than in normal controls （P〈0. 01）. Conclusion： Insulin resistance （IR） exists in lacunar cerebral infarction with elderly hypertension patients and it is an important risk factor in lacunar infarction.