2-托品醇立体异构体的选择性合成

Stereoselective synthesis of isomeric 2tropanols

以２托品酮外消旋体（１），分别经氧化铂催化氢化和金属钠还原，立体选择性制备２α和２β托品醇，再经左旋和右旋酒石酸拆分，得１Ｒ（５Ｓ），２Ｒ；１Ｓ（５Ｒ），２Ｓ；１Ｓ（５Ｒ），２Ｒ和１Ｒ（５Ｓ），２Ｓ托品醇四个光学异构体。

The isomeric 2α(±) and 2β(±)tropanols were prepared stereoselectively from 2(±)tropanone by hydrogenation over platium oxide and reduction with metallic sodium respectively. The optical resolutions were carried out by (+) and (-) tartaric acid into four enantiomers and the configurations were assigned to 1R(5S), 2R; 1S(5R),2S; 1R(5S),2S and 1S(5R),2Rtropanols by comparing with that of the product degraded from L(-)cocaine.