摘要
沙丁胺醇抗豚鼠哮喘作用的昼夜节律马孔琛，王敏，吴华彦（沈阳药科大学生理教研室，沈阳１１００１５）中国图书分类号Ｒ９７４．３提要沙丁胺醇扩张支气管平滑肌作用存在明显的昼夜节律。将动物置光—暗（１２ｈ光照）交迭的小室中饲养１ｗｋ后用于实验。在２４ｈ中的６...
The circadian rhythm of me asthma and the antiasthmatic effects of the salbutamol sulfate were determined in guinea pigs.All aminals were adapted for a minmum period of a week to enviromental room equipped with an automatically timed 12h light and 12h dark illumination cycle befor these experiments.It has been proved that the asthmogenic effects showed circadian rhythms in guinea pigs. The latencies were the longest(102.6±15.5s)in 12:00 h and the shotest(53.2±15.9s)in night 24∶ 00h. The difference was signifcant.The salbutamol sulfate(1mg· kg-1)was administrated at the six different timepoints over the 24 h span.The antiasthmatic effects indicated the remarkable circadian changes in guinea pigs.It was strongest at 1200 h and the weakest in the night. The pharmacodynamics of the night was increased at double dose(2 mg·kg-1).
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第3期260-262,共3页
Chinese Pharmacological Bulletin
