摘要
本文采用环磷酰胺(Cy)诱导免疫功能低下的DTH模型,观察了富硒酵母对DTH的影响.结果发现,Sey(30,60,90mg·kg^(-1)·d^(-1)×6d,ig)对Cy抑制的小鼠DTH有拮抗作用,并能使DTH小鼠低下的脾淋巴细胞ConA增殖反应恢复正常以上;两个较低剂量对Cy所致DTH小鼠免疫器官重量的减轻有抑制作用;两个较高剂量对DTH小鼠低下的脾淋巴细胞LPS增殖反有不同程度的恢复.提示Sey对淋巴细胞的功能有促进作用.
The effects of selenium-enriched yeast (Sey) on DTH in immunosuppressive mice have been investigated. It was found that Sey (30, 60, 90 mg·kg-l·d-1×6 d, ig) was able to antagonize lowered DTH by cyclophospha-mide (Cy); Meanwhile, the thymus and spleen weights were increased by Sey (30, or 60 mg·kg-1·d-1) in immunosuppressive mice. Sey also potentiated the lowered ConA and LPS-indu-ced proliferation of splenocytes in DTH mice at the doses of 30, 60, or 90 mg ·kg-1 and 60 or 90 mg·kg-1 respectively. These results suggested that Sey could enhance the functions of lymphocytes.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第2期182-184,共3页
Chinese Pharmacological Bulletin
关键词
硒
富硒酵母
迟发型变态反应
脾
淋巴细胞
免疫
selenium-enriched yeast
de-layed-type hypersensitivity (DTH)
spleen
lymphocyte
proliferation
