膝关节骨性关节炎与老年2型糖尿病的相关性及易患因素分析

Analysis of Relationship between Osteoarthritis and Type 2 Diabetes

目的对膝关节骨性关节炎与老年2型糖尿病的关性及易患因素进行分析,探讨膝关节骨性关节炎的发病机理,为预防和干预提供依据.方法通过对我院1998年3月～2002年3月183例膝关节骨性关节炎病人和200例老年2型糖尿病病人的相关性进行分析,并对同时患这两种疾病的易患因素进行分析.结果 39.50%的膝关节骨性关节炎病人合并有老年2型糖尿病(P<0.01);49.73%的老年2型糖尿病病人合并有膝关节骨性关节炎(P<0.01),女性老年2型糖尿病并发膝关节骨性关节炎的几率更高(71.29%).同时合并这两种病的病人与性别(OR=2.462)、高血压(OR=4.115)、腰臀比(OR=17.968)、家族史(OR=5.926)有显著性关联.结论老年2型糖尿病与膝关节骨性关节炎有显著相关性,尤其是女性的几率更高.膝关节骨性关节炎可能是代谢综合征的重要一环;及时诊断和治疗老年2型糖尿病对推迟膝关节骨性关节炎的发病时间和减轻膝关节的损坏程度有十分重要的意义,而女性患者更要重视.

Objective To recognize the risk factors and provide evidence for prevention and intervention of oateoarthritis of knee. Methods A frequency matched case-control study based on 183 osteoarthritis of knee eases,200 type 2 diabetes mellitus in the elderly cases and 83 unity cases of osteoarthritis of knee and type 2 diabetes mellitus in the elderly. Results 91eases （49.73%） of type 2 diabetes mellitus in the elderly unite osteoarthritis of knee （P〈 0.01） ,72cases （71.29%）were female;79 cases （39.50%） osteoarthritis of knee of unite type 2 diabetes mellitus in the elderly （P 〈 0.01） ;gender （OR =2. 462）, family history （OR =5. 926） ,hypertension（OR =4. I15） ,WHR （OR =17. 968） were distinctly associated with the unity cases of osteoarthritis of knee and type 2 diabetes mellitus in the elderly. Conclusions The results indicate that type 2 diabetes mellitus in the elderly are distinctly associated with the osteoarthritis of knee. Gender,family history,hypertension and WHR might be risk factors of osteoarthritis of knee unite type 2 diabetes mellitus in the elder. Healthy lifestyle intervention and early diagnosis may provide an effective and protective program.