精神分裂症和心境障碍混合家系5-HTR 6基因多态性的关联分析

Association study between 5 - HTR 6 gene polymorphisms with schizophrenia and mood disorders

目的在中国汉族人群精神分裂症和心境障碍混合家系中探讨五羟色胺6受体(5-HTR 6)基因267C／T多态性与精神分裂症、心境障碍的关联性。方法采用聚合酶链反应-限制性片断长度多态(PCR—RFLP)技术对67例精神病混合家系患者及其父母进行5-HTR 6基因267C／T多态性检测,并予以传递不平衡检验(TDT)。结果患者组与父母组之间,5-HTR6基因267C/T多态性等位基因分布(X2=2．70,υ=1,P>0．05)和基因型分布(X2=2．97,υ=2,P>0．05)无明显差异,5-HTR 6基因 267C／T多态性与精神分裂症(X2=5．16,P<0．05)存在关联,但与心境障碍(X2=2．17,P>0．05)无关联。结论在中国汉族人群中5-HTR 6基因或邻近基因可能是精神分裂症易患基因之一,但可能不是心境障碍的易患基因。

Objective： To explore the relationships between serotonin 6 receptor （5 - HTR 6） gene polymorphisms and schizophrenia, mood disorders in the mixed pedigrees of Chinese Han population. Methods： The 5- HTR 6 SNPs 267C/T were genotyped by applying polymerase chain reaction- restriction fragment length polymorphism （PCR - RLFP） technique in 67 mixed - families of schizophrenia and mood disorders, then transmission disequilibrium test （TDT） was performed. Results：There were no significant difference in alleles （ χ^2 = 2.70, v = 1, P 〉 0.05 ） and genotypes （ χ^2 = 2.97, v = 2, P 〉 0.05 ） distribution between patients and their parents. The SNPs 267C/T was associated with schizophrenia （ χ^2 = 5.16, P 〈 0. 05）, but not associated with mood disorder（ χ^2 = 2. 17, P 〉 0. 05 ）. Conclusion： The 5 -HTR 6 gene or neighboring gene may be one of common susceptible genes for schizophrenia, but not for mood disorders in Chinese Han population.