阿尔茨海默病和血管性痴呆听觉事件相关电位P_(300)比较研究

A comparative study of P_(300) between patients with vascular dementia and Alzheimer's disease

目的探讨阿尔茨海默病(AD)和血管性痴呆(VD)在听觉事件相关电位P300检测中的不同特点。方法收集符合ICD-10诊断标准的30例AD和36例VD患者,并以35例健康老人作对照组(NC)。使用丹麦仪器以及“听觉靶-非靶刺激序列”为诱发事件,完成P300检测。结果 (1)3组在靶潜伏期Cz脑区N2以及在靶波幅C2脑区P2、P3和非靶波幅C2脑区P2上均有显著差异(P<0．01)。 (2)AD主成分N2表现为延迟,与NC组和VD组有极显著性差异(P<0．01)。(3)AD组和VD组靶波幅P3和非靶波幅P2均见降低,与NC组比较也有显著性差异(P<0．05-<0．01)。结论提示作为反映AD和VD认知功能障碍的客观生理指标,P300有可能作为AD和VD辅助诊断的一个脑电生理学标志。P300检查可作为老年神经精神科的必查项目。

Objective： To investigate the ehanges of event related petentials P300 in patients suffering from vascular dementia （VD） and Alzheimerg disease（AD）. Methods： An ‘ oddball＇ paradigm was used to elicit the auditory P300 from 36 patients diagnosed as having VD aeeording to ICD - 10, 30 patients with AD and 35 normally age - matehed eontrols, by using a Darmak Medieal Instrument. Results ： A signifieant differenee of ERP - P300 among 3 subject groups was found with both lateneies （ Cz/N2 ） and amplitudes （ Cz / P2, P3 ） （ P 〈 0.05 -0.01 ）. Compared with NC and VD groups, AD group showed prolonged N2 latency （P 〈 0.01 ）. Compared with NC groups, AD and VD patients showed deereased P3 amplitude from target and P2 amplitude from nontarget （P 〈 0.05 -0.01 ）. Conclusion： Auditory P300 ERP might be an useful physiological index reflecting the eognitive disorder in VD and AD.