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神经病理性痛大鼠脊髓背角神经元凋亡及Bax和Bcl-2的表达 被引量:3

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摘要 早期的组织学研究表明外周神经损伤后脊髓背角抑制性中间神经元可发生跨突触变性死亡[1],近年的研究采用末端生脱氧核糖核苷酸转移酶介导生物素标记(TUNEL)技术证实凋亡是外周神经损伤后脊髓神经元死亡的重要方式[2].
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 2005年第12期932-933,共2页 Chinese Journal of Anesthesiology
基金 江苏省省级高校重点实验室开放课题资助(KJS03083)
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参考文献5

  • 1Sugimoto T,Bennett GJ,Kajander KC.Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury:effects of a chronic constriction injury,transection,and strychnine.Pain,1990,42:205-213.
  • 2Whiteside GT,Munglani R.Cell death in the superficiall dorsal horn in a model of neuropathic pain.J Neurosci Res,2001,64:168-173.
  • 3White FA,Keller-Peck CR,Michael Knudson C,et al.Widespread elimination of naturally occurring neuronal death in Bax -deficient mice.J Neurosci,1998,18:1428-1439.
  • 4Bennett GJ,Xie YK.A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.Pain,1988; 33:87-107.
  • 5Middleton G,Nunea G,Davies A.Bax promotes neuronal survival and antagonizes the survival effects of neurotrophic factors.Developnent,1996,122:695-701.

同被引文献32

  • 1Asher E, Payne CM, Bemstein C. Evaluation of cell death in EBV-transformed lymphocytes using agarose gel electrophoresis, light microscopy and electron microscopy. II. Induction of non-classic apoptosis (" para-apoptosis") by tritiated thymidine. Leuk Lymphoma, 1995,19 : 107- 119.
  • 2Sperandio S, Belle LD, Bredesen DE. An alternative, non-apoptotic form of programmed cell death. Proc Natl Acad Sei USA, 2000, 97 : 14376-14381.
  • 3Clarke PG. Developmental cell death: morphological diversity and multiple mechanisms. Anat Embryol (Berl) 1990,181 : 195- 213.
  • 4Pilar G, Landmesser L. Uhrastructural differences during embryonic cell death in normal and periph- erally deprived ciliary ganglia. J Cell Biol, 1976, 68 : 339 - 356.
  • 5Castro-Obregon S, Del Rio G, Chen SF, et al. A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell Death Differ, 2002,9 : 807 - 817.
  • 6王淳 陈誉华 陈澄.Paraptosis一种新的细胞死亡方式[J].解剖科学进展,1997,8:257-257.
  • 7Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain, 1988, 33 : 87 - 107.
  • 8WHITESIDE G T, MUNGLANI R. Cell death in the superficiall dorsal horn in a model of neuropathic pain[JI. J Neurosci Res, 2001, 64(2): 168-173.
  • 9BENNETT G J, XIE Y K. A peripheral mononeuropathy in rat that produce disorders of pain sensation like those seen in man[J]. Pain, 1988, 33(1): 87-107.
  • 10HOLMBERG K, SHI T J, ALBERS K M, et al. Effect of peripheral nerve lesion and lumbar sympathectomy on peptide regulation in dorsal root ganglia in the NGF-overexpressing mouse[J]. Exp Neurol, 2001, 167(2): 290-303.

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