摘要
瑞香狠毒水提物（ＳｃＬ）抑制小鼠移植肿瘤Ｓ－１８０生长，５－２０ｇ／ｋｇ（相当生药）ｉｐ１０ｄ，抑制率为１６．２－４７．８％。ＳｃＬ对体外培养的Ｓ－１８０细胞生长、集落形成和ＭＴＴ甲化合物生成有显著抑制作用，并和剂量呈正相关。表明ＳｃＬ的抗肿瘤作用是其直接作用于肿瘤细胞所产生。
Effects of Chinese Stellera (Stellera chamaejsme L. ScL) on the growth of mouse tumor S180 in vivo and in vitro were studied. It wsa found that ScL inhibited the growth of transplanted mouse tumor S180,5-20g/kg (equivalent crude drug) ip for 10d, the inhibition rates of it against S180 were 16. 2-47.8%. ScL inhibited the proliferation,MTT formazan formation and clonal formatrion of S-180 celles. The inhibition rate had a positive interrelationship with the concentration and exposure time. These results showed that ScL had an effective antitumor activity in vitro and in vivo.
出处
《药学实践杂志》
CAS
1996年第1期9-11,共3页
Journal of Pharmaceutical Practice
关键词
瑞香狼毒
抗肿瘤作用
S-180
Chinese Stellera (Stellera chamaejasme L.)
antitumor activity
S-180
