摘要
目的观察高同型半胱氨酸血症与脑梗死及TIA之间的关系。方法应用高压液相色谱法(HPLC)对脑梗死、TIA和对照组中的健康体检者进行血浆同型半胱氨酸测定。结果脑梗死组病人的血浆同型半胱氨酸水平明显高于对照组(P<0.01),而TIA组病人的血浆同型半胱氨酸水平高于对照组但无显著性差异(P>0.05)。结论高同型半胱氨酸血症主要损伤中等及大血管而不是小血管。
Objective To observe the possibility that the association between hyperhomocysteinemia （HHcy） and cerebral infarction （CI） and transient ischemic attacks （TIA）. Methods Consecutive cases with new cerebral infarction/TIA were compared with controls. The concentration of plasma homocysteine （Hcy） in patients with cerebral infarct/TIA and healthy controls was measured using high performance liquid chromatography （HPLC）. Results The mean concentration of Hcy in CI group was found to be significantly higher than that of normal controls （p 〈 0. 01 ）. The mean concentration of Hcy in TIA group was found higher than that of normal controls but without significantly （ P 〉 0.05）. Conclusiion HHcy would be associated with largemedium vessel rather than with small vessel disease.
