血清急性期蛋白EB病毒IgA／VCA，IgA／EA抗体测定在鼻咽癌诊断中的应用

APPLICATION OF SERUM ACUTE PHASE PROTEINSAND EBV IgA/VCA,IgA/EA DETERMINATION IN DI- AGNOSIS OF NASOPHAKYNGEAL CARCTNOMA

测定１９０例鼻咽癌（ＮＰＣ）患者血清中急性期蛋白（ＡＰＰＳ）包括：唾液酸（ＳＡ）．α＿１－抗胰蛋白酶（α＿１－ＡＴ），α＿１－酸性糖蛋白（ａα＿１－ＡＧＰ），触珠蛋白（ＨＰ），铁传递蛋白（ＴＦ）和前清蛋白（ＰＡ）及ＥＢ病毒（ＥＢＶ）ＩｇＡ／ＶＣＡ，ＩｇＡ／ＥＡ抗体，并评价ＡＰＰＳ和ＥＢＶＩｇＡ／ＶＣＡ，ＩｇＡ／ＥＡ抗体对鼻咽癌的诊断价值。。将ＡＰＰＳ测定值经逐步判别分析统计学处理，求得判别函数，用以对ＮＰＣ进行判别诊断。结果发现：ＮＰＣ治疗前组ＡＮＰＳＥＢＶＩｇＡ／ＶＣＡ，ＩｇＡ／ＥＡ与临床病理诊断的符合率分别为８１．８８％和５６．５７％，而治疗后未复发组两者的符合率分别为８０．９５％和３３．３３％。结果表明：对ＮＰＣ的诊断和随访ＡＰＰＳ优于ＥＢＶＩｇＡ／ＶＣＡ，ＩｇＡ／ＥＡ抗体。

To evaluate the diagnostic value of acute phase proteins(APPS)and EBV IgA/VCA,IgA/EA for nasopharyngeal carcinoma(NPC),the serum APPs including sialic acid(SA),al-antit- rypsin(a1-AT),a1-acidyglycoproteins(a1-AGP),Haptoglobin(HP),Transferrin(TF),and preal-bumin(PA)and EBV IgA/VCA,IgA/EA were determinated in 190 patients with NPC.The dis-criminatnt function equations,with wich the disriminant diagnosis for NPC was 'made, were obtamed by stepwise discriminant analysis with APPs.It was found that in pretreated NpC group the agreement rates of APPs and EBV-IgA/ VCA,IgA/EA with clinical patholgical diagnosis were 81.88 % and 56.57% respoctively,but in treated caseswithout evidence of recurrence were 80.95 % and 28.57 % respectively. Our results suggested that the APPs werebetter than EBV IgA/VCA,IgA/EA for diagnosis and follow-up of NPC.