前列腺素E_1治疗慢性乙型肝炎黄疸的观察

Clinical evaluation of prostaglandin E_1 in treatment of serious icterohepatitis chronic hepatitis

目的观察前列腺素E1治疗慢性乙型肝炎重度黄疸的疗效。方法在综合治疗基础上,分别使用前列腺素E1(治疗组)和门冬氨酸钾镁(对照组)治疗慢性乙型肝炎重度黄疸患者各35例,并观察其症状、体征及肝、肾功能等,疗程4周。结果治疗组的症状、体征及肝功能指标及总有效率,均显著优于对照组,两组比较差异有显著意义(P<0.05)。结论前列腺素E1治疗慢性乙型肝炎重度黄疸能显著地促进黄疸消退和改善肝功能。

Objective To study thetherapeutic action of prostaglandin E1 on serious icterohepatitis chronic hepatitis B. Methods Prospective tests were carried out by random comparision and uni-biind means. 70 cases of serious chronic hepatitis B ieterohepatitis were randomly divided into active group and control group. On the basis of combined treatment, active group was treated with prostaglandin E1 100μg, control group was treated with 20ml potassium-magnesium aspartate injection, both in 150ml 0.9 96 sodium chloride solution and injected intravenously once daily for 4 weeks. Results Toral effective rate of active group was 68.5 % ,which was notably higher than 42.9 % ,that of control group （ P 〈 0.05 ）. Conclusion The effect of prostaglandin E1 on serious icterohepatitis chronic hepatitis B is better than potassium-magnesium aspartate injection, which can evidently promote icteric to fadeaway and improve liver function,with little side-effect.